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The character of the muscarinic receptors in different regions of the rat brain

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Published:13 February 1980https://doi.org/10.1098/rspb.1980.0011

Abstract

The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown that in all regions there are three classes of receptors with similar binding characteristics but that these are present in different proportions. The binding constants to the three receptor types of a range of agonists were examined and evidence was produced in support of the theory that the subclasses of brain receptors are due to a single receptor subunit subject to different conformational constraints.

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This Issue

13 February 1980

Volume 207Issue 1166

Article Information

DOI:https://doi.org/10.1098/rspb.1980.0011
PubMed:6102394
Published by:Royal Society
Print ISSN:0080-4649
Online ISSN:2053-9193

History:

Manuscript received03/07/1979
Published online01/01/1997
Published in print13/02/1980

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