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Philosophical Transactions of the Royal Society B: Biological Sciences
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Gastrointestinal hormones regulating appetite

Published:15 June 2006https://doi.org/10.1098/rstb.2006.1856

    Abstract

    The role of gastrointestinal hormones in the regulation of appetite is reviewed. The gastrointestinal tract is the largest endocrine organ in the body. Gut hormones function to optimize the process of digestion and absorption of nutrients by the gut. In this capacity, their local effects on gastrointestinal motility and secretion have been well characterized. By altering the rate at which nutrients are delivered to compartments of the alimentary canal, the control of food intake arguably constitutes another point at which intervention may promote efficient digestion and nutrient uptake. In recent decades, gut hormones have come to occupy a central place in the complex neuroendocrine interactions that underlie the regulation of energy balance.

    Many gut peptides have been shown to influence energy intake. The most well studied in this regard are cholecystokinin (CCK), pancreatic polypeptide, peptide YY, glucagon-like peptide-1 (GLP-1), oxyntomodulin and ghrelin. With the exception of ghrelin, these hormones act to increase satiety and decrease food intake. The mechanisms by which gut hormones modify feeding are the subject of ongoing investigation.

    Local effects such as the inhibition of gastric emptying might contribute to the decrease in energy intake. Activation of mechanoreceptors as a result of gastric distension may inhibit further food intake via neural reflex arcs. Circulating gut hormones have also been shown to act directly on neurons in hypothalamic and brainstem centres of appetite control. The median eminence and area postrema are characterized by a deficiency of the blood–brain barrier. Some investigators argue that this renders neighbouring structures, such as the arcuate nucleus of the hypothalamus and the nucleus of the tractus solitarius in the brainstem, susceptible to influence by circulating factors. Extensive reciprocal connections exist between these areas and the hypothalamic paraventricular nucleus and other energy-regulating centres of the central nervous system. In this way, hormonal signals from the gut may be translated into the subjective sensation of satiety. Moreover, the importance of the brain–gut axis in the control of food intake is reflected in the dual role exhibited by many gut peptides as both hormones and neurotransmitters. Peptides such as CCK and GLP-1 are expressed in neurons projecting both into and out of areas of the central nervous system critical to energy balance.

    The global increase in the incidence of obesity and the associated burden of morbidity has imparted greater urgency to understanding the processes of appetite control. Appetite regulation offers an integrated model of a brain–gut axis comprising both endocrine and neurological systems. As physiological mediators of satiety, gut hormones offer an attractive therapeutic target in the treatment of obesity.

    References

    • Abbott C.R, Monteiro M, Small C.J, Sajedi A, Smith K.L, Parkinson J.R, Ghatei M.A& Bloom S.RThe inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway. Brain Res. 1044, 2005a127–131.doi:10.1016/j.brainres.2005.03.011. . Crossref, PubMed, ISI, Google Scholar
    • Abbott C.R, Small C.J, Kennedy A.R, Neary N.M, Sajedi A, Ghatei M.A& Bloom S.RBlockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Res. 1043, 2005b139–144.doi:10.1016/j.brainres.2005.02.065. . Crossref, PubMed, ISI, Google Scholar
    • Adams S.H, Won W.B, Schonhoff S.E, Leiter A.B& Paterniti J.R. 2004Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology. 145, 4967–4975.doi:10.1210/en.2004-0518. . Crossref, PubMed, ISI, Google Scholar
    • Adrian T.E, Bloom S.R, Bryant M.G, Polak J.M, Heitz P.H& Barnes A.J. 1976Distribution and release of human pancreatic polypeptide. Gut. 17, 940–944. Crossref, PubMed, ISI, Google Scholar
    • Adrian T.E, Ferri G.L, Bacarese-Hamilton A.J, Fuessl H.S, Polak J.M& Bloom S.RHuman distribution and release of a putative new gut hormone, peptide YY. Gastroenterology. 89, 1985a1070–1077. Crossref, PubMed, ISI, Google Scholar
    • Adrian T.E, Savage A.P, Sagor G.R, Allen J.M, Bacarese-Hamilton A.J, Tatemoto K, Polak J.M& Bloom S.REffect of peptide YY on gastric, pancreatic, and biliary function in humans. Gastroenterology. 89, 1985b494–499. Crossref, PubMed, ISI, Google Scholar
    • Adrian T.E, Savage A.P, Bacarese-Hamilton A.J, Wolfe K, Besterman H.S& Bloom S.R. 1986Peptide YY abnormalities in gastrointestinal diseases. Gastroenterology. 90, 379–384. Crossref, PubMed, ISI, Google Scholar
    • Allen J.M, Fitzpatrick M.L, Yeats J.C, Darcy K, Adrian T.E& Bloom S.R. 1984Effects of peptide YY and neuropeptide Y on gastric emptying in man. Digestion. 30, 255–262. Crossref, PubMed, ISI, Google Scholar
    • Alvarez B.M, Borque M, Martinez-Sarmiento J, Aparicio E, Hernandez C, Cabrerizo L& Fernandez-Represa J.A. 2002Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty. Obes. Surg. 12, 324–327. Crossref, PubMed, ISI, Google Scholar
    • Amland P.F, Jorde R, Kildebo S, Burhol P.G& Giercksky K.E. 1984Effects of a gastric partitioning operation for morbid obesity on the secretion of gastric inhibitory polypeptide and pancreatic polypeptide. Scand. J. Gastroenterol. 19, 857–861. Crossref, PubMed, ISI, Google Scholar
    • Arosio M, Ronchi C.L, Gebbia C, Cappiello V, Beck-Peccoz P& Peracchi M. 2003Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. J. Clin. Endocrinol. Metab. 88, 701–704.doi:10.1210/jc.2002-021161. . Crossref, PubMed, ISI, Google Scholar
    • Asakawa A, Inui A, Momose K, Ueno N, Fujino M.A& Kasuga M. 1998Motilin increases food intake in mice. Peptides. 19, 987–990.doi:10.1016/S0196-9781(97)00477-4. . Crossref, PubMed, ISI, Google Scholar
    • Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino M.A& Kasuga M. 1999Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides. 20, 1445–1448.doi:10.1016/S0196-9781(99)00155-2. . Crossref, PubMed, ISI, Google Scholar
    • Asakawa A, et al.2003Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 124, 1325–1336.doi:10.1016/S0016-5085(03)00216-6. . Crossref, PubMed, ISI, Google Scholar
    • Atkinson R.L& Brent E.L. 1982Appetite suppressant activity in plasma of rats after intestinal bypass surgery. Am. J. Physiol. 243, R60–R64. PubMed, ISI, Google Scholar
    • Baggio L.L, Huang Q, Brown T.J& Drucker D.J. 2004Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology. 127, 546–558.doi:10.1053/j.gastro.2004.04.063. . Crossref, PubMed, ISI, Google Scholar
    • Baldwin B.A, Parrott R.F& Ebenezer I.S. 1998Food for thought: a critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor. Prog. Neurobiol. 55, 477–507.doi:10.1016/S0301-0082(98)00005-7. . Crossref, PubMed, ISI, Google Scholar
    • Banks W.A, Kastin A.J& Jaspan J.B. 1995Regional variation in transport of pancreatic polypeptide across the blood–brain barrier of mice. Pharmacol. Biochem. Behav. 51, 139–147.doi:10.1016/0091-3057(94)00412-C. . Crossref, PubMed, ISI, Google Scholar
    • Barden N, Merand Y, Rouleau D, Moore S, Dockray G.J& Dupont A. 1981Regional distributions of somatostatin and cholecystokinin-like immunoreactivities in rat and bovine brain. Peptides. 2, 299–302.doi:10.1016/0196-9781(81)90048-6. . Crossref, PubMed, ISI, Google Scholar
    • Batterham R.L, et al.2002Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 418, 650–654.doi:10.1038/nature00887. . Crossref, PubMed, ISI, Google Scholar
    • Batterham R.L, Cohen M.A, Ellis S.M, Le Roux C.W, Withers D.J, Frost G.S, Ghatei M.A& Bloom S.RInhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 349, 2003a941–948.doi:10.1056/NEJMoa030204. . Crossref, PubMed, ISI, Google Scholar
    • Batterham R.L, Le Roux C.W, Cohen M.A, Park A.J, Ellis S.M, Patterson M, Frost G.S, Ghatei M.A& Bloom S.RPancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 88, 2003b3989–3992.doi:10.1210/jc.2003-030630. . Crossref, PubMed, ISI, Google Scholar
    • Bayliss H.P& Starling E.H. 1902Mechanism of pancreatic secretion. J. Physiol. Lond. 28, 325–353. Crossref, Google Scholar
    • Beinfeld M.C& Bailey G.J. 1985The distribution of motilin-like peptides in rhesus monkey brain as determined by radioimmunoassay. Neurosci. Lett. 54, 345–350. Crossref, PubMed, ISI, Google Scholar
    • Bell G.I, Yasuda K, Kong H, Law S.F, Raynor K& Reisine T. 1995Molecular biology of somatostatin receptors. Ciba Found. Symp. 190, 65–79. PubMed, Google Scholar
    • Berglund M.M, Hipskind P.A& Gehlert D.R. 2003Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp. Biol. Med. (Maywood.). 228, 217–244. Crossref, PubMed, ISI, Google Scholar
    • Berntson G.G, Zipf W.B, O'Dorisio T.M, Hoffman J.A& Chance R.E. 1993Pancreatic polypeptide infusions reduce food intake in Prader–Willi syndrome. Peptides. 14, 497–503.doi:10.1016/0196-9781(93)90138-7. . Crossref, PubMed, ISI, Google Scholar
    • Berrettini W.H, Kaye W.H, Gwirtsman H& Allbright A. 1988Cerebrospinal fluid peptide YY immunoreactivity in eating disorders. Neuropsychobiology. 19, 121–124. Crossref, PubMed, ISI, Google Scholar
    • Besterman H.S, Cook G.C, Sarson D.L, Christofides N.D, Bryant M.G, Gregor M& Bloom S.R. 1979Gut hormones in tropical malabsorption. Br. Med. J. 2, 1252–1255. Crossref, PubMed, Google Scholar
    • Bi S, Ladenheim E.E, Schwartz G.J& Moran T.H. 2001A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R254–R260. Crossref, PubMed, ISI, Google Scholar
    • Blevins J.E, Stanley B.G& Reidelberger R.D. 2000Brain regions where cholecystokinin suppresses feeding in rats. Brain Res. 860, 1–10.doi:10.1016/S0006-8993(99)02477-4. . Crossref, PubMed, ISI, Google Scholar
    • Broberger C, Landry M, Wong H, Walsh J.N& Hokfelt T. 1997Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology. 66, 393–408. Crossref, PubMed, ISI, Google Scholar
    • Buffa R, Solcia E& Go V.L. 1976Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology. 70, 528–532. Crossref, PubMed, ISI, Google Scholar
    • Campbell R.E, Smith M.S, Allen S.E, Grayson B.E, Ffrench-Mullen J.M& Grove K.L. 2003Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J. Neurosci. 23, 1487–1497. Crossref, PubMed, ISI, Google Scholar
    • Challis B.G, Pinnock S.B, Coll A.P, Carter R.N, Dickson S.L& O'Rahilly S. 2003Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem. Biophys. Res. Commun. 311, 915–919.doi:10.1016/j.bbrc.2003.10.089. . Crossref, PubMed, ISI, Google Scholar
    • Challis B.G, et al.2004Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc. Natl Acad. Sci. USA. 101, 4695–4700.doi:10.1073/pnas.0306931101. . Crossref, PubMed, ISI, Google Scholar
    • Chance W.T, Balasubramaniam A, Zhang F.S, Wimalawansa S.J& Fischer J.E. 1991Anorexia following the intrahypothalamic administration of amylin. Brain Res. 539, 352–354.doi:10.1016/0006-8993(91)91644-G. . Crossref, PubMed, ISI, Google Scholar
    • Chance W.T, Balasubramaniam A, Stallion A& Fischer J.E. 1993Anorexia following the systemic injection of amylin. Brain Res. 607, 185–188.doi:10.1016/0006-8993(93)91505-M. . Crossref, PubMed, ISI, Google Scholar
    • Chelikani P.K, Haver A.C& Reidelberger R.D. 2005Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats. Endocrinology. 146, 879–888.doi:10.1210/en.2004-1138. . Crossref, PubMed, ISI, Google Scholar
    • Clark J.T, Sahu A, Kalra P.S, Balasubramaniam A& Kalra S.P. 1987Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Met17]NPY), NPY analog ([norLeu4]NPY) and peptide YY. Regul. Pept. 17, 31–39.doi:10.1016/0167-0115(87)90030-9. . Crossref, PubMed, Google Scholar
    • Cohen M.A, Ellis S.M, Le Roux C.W, Batterham R.L, Park A, Patterson M, Frost G.S, Ghatei M.A& Bloom S.R. 2003Oxyntomodulin suppresses appetite and reduces food intake in humans. J. Clin. Endocrinol. Metab. 88, 4696–4701.doi:10.1210/jc.2003-030421. . Crossref, PubMed, ISI, Google Scholar
    • Cone R.D, Cowley M.A, Butler A.A, Fan W, Marks D.L& Low M.J. 2001The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 25, Suppl. 5, S63–S67. Crossref, PubMed, ISI, Google Scholar
    • Conlon J.M. 2002The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP). Peptides. 23, 269–278.doi:10.1016/S0196-9781(01)00608-8. . Crossref, PubMed, ISI, Google Scholar
    • Conover K.L, Collins S.M& Weingarten H.P. 1989Gastric emptying changes are neither necessary nor sufficient for CCK-induced satiety. Am. J. Physiol. 256, R56–R62. PubMed, ISI, Google Scholar
    • Corp E.S, Melville L.D, Greenberg D, Gibbs J& Smith G.P. 1990Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors. Am. J. Physiol. 259, R317–R323. PubMed, ISI, Google Scholar
    • Corp E.S, McQuade J, Krasnicki S& Conze D.B. 2001Feeding after fourth ventricular administration of neuropeptide Y receptor agonists in rats. Peptides. 22, 493–499.doi:10.1016/S0196-9781(01)00359-X. . Crossref, PubMed, ISI, Google Scholar
    • Crawley J.N& Beinfeld M.C. 1983Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature. 302, 703–706.doi:10.1038/302703a0. . Crossref, PubMed, ISI, Google Scholar
    • Cummings D.E, Purnell J.Q, Frayo R.S, Schmidova K, Wisse B.E& Weigle D.S. 2001A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 50, 1714–1719. Crossref, PubMed, ISI, Google Scholar
    • Cummings D.E, Weigle D.S, Frayo R.S, Breen P.A, Ma M.K, Dellinger E.P& Purnell J.Q. 2002Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346, 1623–1630.doi:10.1056/NEJMoa012908. . Crossref, PubMed, ISI, Google Scholar
    • Dakin C.L, Gunn I, Small C.J, Edwards C.M, Hay D.L, Smith D.M, Ghatei M.A& Bloom S.R. 2001Oxyntomodulin inhibits food intake in the rat. Endocrinology. 142, 4244–4250.doi:10.1210/en.142.10.4244. . Crossref, PubMed, ISI, Google Scholar
    • Dakin C.L, Small C.J, Park A.J, Seth A, Ghatei M.A& Bloom S.R. 2002Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats. Am. J. Physiol. Endocrinol. Metab. 283, E1173–E1177. Crossref, PubMed, ISI, Google Scholar
    • Dakin C.L, Small C.J, Batterham R.L, Neary N.M, Cohen M.A, Patterson M, Ghatei M.A& Bloom S.R. 2004Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology. 145, 2687–2695.doi:10.1210/en.2003-1338. . Crossref, PubMed, ISI, Google Scholar
    • Damholt A.B, Buchan A.M, Holst J.J& Kofod H. 1999Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2. Endocrinology. 140, 4800–4808.doi:10.1210/en.140.10.4800. . Crossref, PubMed, ISI, Google Scholar
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal M.S, Suganuma T, Matsukura S, Kangawa K& Nakazato M. 2000Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 141, 4255–4261.doi:10.1210/en.141.11.4255. . Crossref, PubMed, ISI, Google Scholar
    • Deacon C.F. 2004Therapeutic strategies based on glucagon-like peptide 1. Diabetes. 53, 2181–2189. Crossref, PubMed, ISI, Google Scholar
    • Dillon J.S, Tanizawa Y, Wheeler M.B, Leng X.H, Ligon B.B, Rabin D.U, Yoo-Warren H, Permutt M.A& Boyd A.E. 1993Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology. 133, 1907–1910.doi:10.1210/en.133.4.1907. . Crossref, PubMed, ISI, Google Scholar
    • DiMaggio D.A, Chronwall B.M, Buchanan K& O'Donohue T.L. 1985Pancreatic polypeptide immunoreactivity in rat brain is actually neuropeptide Y. Neuroscience. 15, 1149–1157.doi:10.1016/0306-4522(85)90259-3. . Crossref, PubMed, ISI, Google Scholar
    • Dockray G.J. 2004Clinical endocrinology and metabolism. Gastrin. Best Pract. Res. Clin. Endocrinol. Metab. 18, 555–568.doi:10.1016/j.beem.2004.07.003. . Crossref, PubMed, ISI, Google Scholar
    • Dockray G.J, Varro A, Dimaline R& Wang T. 2001The gastrins: their production and biological activities. Annu. Rev. Physiol. 63, 119–139.doi:10.1146/annurev.physiol.63.1.119. . Crossref, PubMed, ISI, Google Scholar
    • Dube P.E& Brubaker P.L. 2004Nutrient, neural and endocrine control of glucagon-like peptide secretion. Horm. Metab. Res. 36, 755–760. Crossref, PubMed, ISI, Google Scholar
    • Dubrasquet M, Bataille D& Gespach C. 1982Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): a potent inhibitor of pentagastrin-stimulated acid secretion in rats. Biosci. Rep. 2, 391–395.doi:10.1007/BF01119301. . Crossref, PubMed, ISI, Google Scholar
    • Eberlein G.A, et al.1989A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36). Peptides. 10, 797–803.doi:10.1016/0196-9781(89)90116-2. . Crossref, PubMed, ISI, Google Scholar
    • Edvell A& Lindstrom P. 1999Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/?). Endocrinology. 140, 778–783.doi:10.1210/en.140.2.778. . Crossref, PubMed, ISI, Google Scholar
    • Edwards C.M, Edwards A.V& Bloom S.R. 1997Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf. Exp. Physiol. 82, 709–716. Crossref, PubMed, ISI, Google Scholar
    • Edwards C.M, Stanley S.A, Davis R, Brynes A.E, Frost G.S, Seal L.J, Ghatei M.A& Bloom S.R. 2001Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am. J. Physiol. Endocrinol. Metab. 281, E155–E161. Crossref, PubMed, ISI, Google Scholar
    • Eissele R, Goke R, Willemer S, Harthus H.P, Vermeer H, Arnold R& Goke B. 1992Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur. J. Clin. Invest. 22, 283–291. Crossref, PubMed, ISI, Google Scholar
    • Ekblad E& Sundler F. 2002Distribution of pancreatic polypeptide and peptide YY. Peptides. 23, 251–261.doi:10.1016/S0196-9781(01)00601-5. . Crossref, PubMed, ISI, Google Scholar
    • Ekman R, Wahlestedt C, Bottcher G, Sundler F, Hakanson R& Panula P. 1986Peptide YY-like immunoreactivity in the central nervous system of the rat. Regul. Pept. 16, 157–168.doi:10.1016/0167-0115(86)90059-5. . Crossref, PubMed, Google Scholar
    • Ellacott K.L& Cone R.D. 2004The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog. Horm. Res. 59, 395–408.doi:10.1210/rp.59.1.395. . Crossref, PubMed, Google Scholar
    • El Salhy M, Suhr O& Danielsson A. 2002Peptide YY in gastrointestinal disorders. Peptides. 23, 397–402.doi:10.1016/S0196-9781(01)00617-9. . Crossref, PubMed, ISI, Google Scholar
    • Farooqi I.S& O'Rahilly S. 2005Monogenic obesity in humans. Annu. Rev. Med. 56, 443–458.doi:10.1146/annurev.med.56.062904.144924. . Crossref, PubMed, ISI, Google Scholar
    • Fehmann H.C, Jiang J, Schweinfurth J, Wheeler M.B, Boyd A.E& Goke B. 1994Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39). Peptides. 15, 453–456.doi:10.1016/0196-9781(94)90204-6. . Crossref, PubMed, ISI, Google Scholar
    • Feinle C, Chapman I.M, Wishart J& Horowitz M. 2002Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men. Peptides. 23, 1491–1495.doi:10.1016/S0196-9781(02)00087-6. . Crossref, PubMed, ISI, Google Scholar
    • Fong T.M. 2005Advances in anti-obesity therapeutics. Expert. Opin. Invest. Drugs. 14, 243–250.doi:10.1517/13543784.14.3.243. . Crossref, PubMed, ISI, Google Scholar
    • Fu-Cheng X, Anini Y, Chariot J, Castex N, Galmiche J.P& Roze C. 1997Mechanisms of peptide YY release induced by an intraduodenal meal in rats: neural regulation by proximal gut. Pflugers Arch. 433, 571–579.doi:10.1007/s004240050316. . Crossref, PubMed, ISI, Google Scholar
    • Fuhlendorff J, Johansen N.L, Melberg S.G, Thogersen H& Schwartz T.W. 1990The antiparallel pancreatic polypeptide fold in the binding of neuropeptide Y to Y1 and Y2 receptors. J. Biol. Chem. 265, 11 706–11 712. Crossref, ISI, Google Scholar
    • Fujimoto K, Cardelli J.A& Tso P. 1992Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. Am. J. Physiol. 262, G1002–G1006. PubMed, Google Scholar
    • Fujimoto K, Fukagawa K, Sakata T& Tso P. 1993Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats. J. Clin. Invest. 91, 1830–1833. Crossref, PubMed, ISI, Google Scholar
    • Fujimoto S, et al.1997Increased cholecystokinin and pancreatic polypeptide responses to a fat-rich meal in patients with restrictive but not bulimic anorexia nervosa. Biol. Psychiatry. 41, 1068–1070.doi:10.1016/S0006-3223(97)00044-9. . Crossref, PubMed, ISI, Google Scholar
    • Funakoshi A, Miyazaki K& Nawata H. 1989Effect of secretin and caerulein on pancreatic polypeptide and on insulin secretion from the isolated perfused ventral area of the rat pancreas. Regul. Pept. 24, 111–116.doi:10.1016/0167-0115(89)90216-4. . Crossref, PubMed, Google Scholar
    • Gallwitz B, Witt M, Folsch U.R, Creutzfeldt W& Schmidt W.E. 1993Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells. J. Mol. Endocrinol. 10, 259–268. Crossref, PubMed, ISI, Google Scholar
    • Garthwaite T.L. 1985Peripheral motilin administration stimulates feeding in fasted rats. Peptides. 6, 41–44.doi:10.1016/0196-9781(85)90074-9. . Crossref, PubMed, ISI, Google Scholar
    • Gehlert D.R, Schober D.A, Beavers L, Gadski R, Hoffman J.A, Smiley D.L, Chance R.E, Lundell I& Larhammar D. 1996Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. Mol. Pharmacol. 50, 112–118. PubMed, ISI, Google Scholar
    • Gendall K.A, Kaye W.H, Altemus M, McConaha C.W& La Via M.C. 1999Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients. Biol. Psychiatry. 46, 292–299.doi:10.1016/S0006-3223(98)00292-3. . Crossref, PubMed, ISI, Google Scholar
    • Ghatei M.A, Uttenthal L.O, Christofides N.D, Bryant M.G& Bloom S.R. 1983Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. J. Clin. Endocrinol. Metab. 57, 488–495. Crossref, PubMed, ISI, Google Scholar
    • Gibbs J, Young R.C& Smith G.P. 1973Cholecystokinin decreases food intake in rats. J. Comp. Physiol. Psychol. 84, 488–495. Crossref, PubMed, ISI, Google Scholar
    • Gingerich R.L, Akpan J.O, Gilbert W.R, Leith K.M, Hoffmann J.A& Chance R.E. 1991Structural requirements of pancreatic polypeptide receptor binding. Am. J. Physiol. 261, E319–E324. PubMed, ISI, Google Scholar
    • Glaser B, Zoghlin G, Pienta K& Vinik A.I. 1988Pancreatic polypeptide response to secretin in obesity: effects of glucose intolerance. Horm. Metab. Res. 20, 288–292. Crossref, PubMed, ISI, Google Scholar
    • Glatzle J, Kalogeris T.J, Zittel T.T, Guerrini S, Tso P& Raybould H.E. 2002Chylomicron components mediate intestinal lipid-induced inhibition of gastric motor function. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G86–G91. Crossref, PubMed, ISI, Google Scholar
    • Gomez G, Udupi V& Greeley G.H. 1997Comparison of somatostatin and pancreastatin on secretion of gastrin, pancreatic polypeptide, and peptide YY. Proc. Soc. Exp. Biol. Med. 215, 165–167. Crossref, PubMed, ISI, Google Scholar
    • Gorrell M.D, Gysbers V& McCaughan G.W. 2001CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand. J. Immunol. 54, 249–264.doi:10.1046/j.1365-3083.2001.00984.x. . Crossref, PubMed, ISI, Google Scholar
    • Grandt D, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein V.E& Reeve J.R. 1994Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul. Pept. 51, 151–159.doi:10.1016/0167-0115(94)90204-6. . Crossref, PubMed, Google Scholar
    • Gustafson E.L, Smith K.E, Durkin M.M, Walker M.W, Gerald C, Weinshank R& Branchek T.A. 1997Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Brain Res. Mol. Brain Res. 46, 223–235.doi:10.1016/S0169-328X(97)00017-X. . Crossref, PubMed, Google Scholar
    • Gutzwiller J.P, Drewe J, Goke B, Schmidt H, Rohrer B, Lareida J& Beglinger CGlucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am. J. Physiol. 276, 1999aR1541–R1544. PubMed, Google Scholar
    • Gutzwiller J.P, Goke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, Winterhalder R, Conen D& Beglinger CGlucagon-like peptide-1: a potent regulator of food intake in humans. Gut. 44, 1999b81–86. Crossref, PubMed, ISI, Google Scholar
    • Halatchev I.G, Ellacott K.L, Fan W& Cone R.D. 2004Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology. 145, 2585–2590.doi:10.1210/en.2003-1754. . Crossref, PubMed, ISI, Google Scholar
    • Hanusch-Enserer U& Roden M. 2005News in gut–brain communication: a role of peptide YY (PYY) in human obesity and following bariatric surgery?. Eur. J. Clin. Invest. 35, 425–430.doi:10.1111/j.1365-2362.2005.01514.x. . Crossref, PubMed, ISI, Google Scholar
    • Hayes M.R, Moore R.L, Shah S.M& Covasa M. 20045-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R817–R823. Crossref, PubMed, ISI, Google Scholar
    • Hoentjen F, Hopman W.P& Jansen J.B. 2001Effect of circulating peptide YY on gallbladder emptying in humans. Scand. J. Gastroenterol. 36, 1086–1091.doi:10.1080/003655201750422710. . Crossref, PubMed, ISI, Google Scholar
    • Holst J.J. 2004On the physiology of GIP and GLP-1. Horm. Metab. Res. 36, 747–754.doi:10.1055/s-2004-826158. . Crossref, PubMed, ISI, Google Scholar
    • Holst J.J. 2005Glucagon-like peptide-1: physiology and therapeutic potential. Curr. Opin. Endocrinol. Diab. 12, 56–62.doi:10.1097/01.med.0000151395.52819.47. . Crossref, Google Scholar
    • Holst J.J, Sorensen T.I, Andersen A.N, Stadil F, Andersen B, Lauritsen K.B& Klein H.C. 1979Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio. Scand. J. Gastroenterol. 14, 205–207. Crossref, PubMed, ISI, Google Scholar
    • Holst J.J, Orskov C, Nielsen O.V& Schwartz T.W. 1987Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett. 211, 169–174.doi:10.1016/0014-5793(87)81430-8. . Crossref, PubMed, ISI, Google Scholar
    • Hort Y, Baker E, Sutherland G.R, Shine J& Herzog H. 1995Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. Genomics. 26, 77–83.doi:10.1016/0888-7543(95)80085-Z. . Crossref, PubMed, ISI, Google Scholar
    • Hutchison J.B, Dimaline R& Dockray G.J. 1981Neuropeptides in the gut: quantification and characterization of cholecystokinin octapeptide-, bombesin- and vasoactive intestinal polypeptide-like immunoreactivities in the myenteric plexus of the guinea-pig small institute. Peptides. 2, 23–30. Crossref, PubMed, ISI, Google Scholar
    • Inui A, Mizuno N, Ooya M, Suenaga K, Morioka H, Ogawa T, Ishida M& Baba S. 1985Cross-reactivities of neuropeptide Y and peptide YY with pancreatic polypeptide antisera: evidence for the existence of pancreatic polypeptide in the brain. Brain Res. 330, 386–389.doi:10.1016/0006-8993(85)90704-8. . Crossref, PubMed, ISI, Google Scholar
    • Itoh Z. 1997Motilin and clinical application. Peptides. 18, 593–608.doi:10.1016/S0196-9781(96)00333-6. . Crossref, PubMed, ISI, Google Scholar
    • Jang J.Y, Kim S.W, Ku J.L, Park Y.H& Park J.G. 2005Presence of CCK-A, B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary cancer cell lines. World J. Gastroenterol. 11, 803–809. Crossref, PubMed, ISI, Google Scholar
    • Jorde R& Burhol P.G. 1982Effect of jejunoileal bypass operation and Billroth II resection on postprandial plasma pancreatic polypeptide release. Scand. J. Gastroenterol. 17, 613–617. Crossref, PubMed, ISI, Google Scholar
    • Jorde R& Burhol P.G. 1984Fasting and postprandial plasma pancreatic polypeptide (PP) levels in obesity. Int. J. Obes. 8, 393–397. PubMed, ISI, Google Scholar
    • Kanatani A, et al.2000Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 141, 1011–1016.doi:10.1210/en.141.3.1011. . Crossref, PubMed, ISI, Google Scholar
    • Katsuura G, Asakawa A& Inui A. 2002Roles of pancreatic polypeptide in regulation of food intake. Peptides. 23, 323–329.doi:10.1016/S0196-9781(01)00604-0. . Crossref, PubMed, ISI, Google Scholar
    • Kazanjian K.K, Towfigh S& McFadden D.W. 2003Peptide YY exhibits a mitogenic effect on pancreatic cells while improving acute pancreatitis in vitro. J. Surg. Res. 114, 95–99.doi:10.1016/S0022-4804(03)00218-X. . Crossref, PubMed, ISI, Google Scholar
    • Kieffer T.J& Habener J.F. 1999The glucagon-like peptides. Endocr. Rev. 20, 876–913.doi:10.1210/er.20.6.876. . Crossref, PubMed, ISI, Google Scholar
    • Kieffer T.J, McIntosh C.H& Pederson R.A. 1995Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology. 136, 3585–3596.doi:10.1210/en.136.8.3585. . Crossref, PubMed, ISI, Google Scholar
    • Kinzig K.P, D'Alessio D.A& Seeley R.J. 2002The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J. Neurosci. 22, 10 470–10 476. Crossref, ISI, Google Scholar
    • Kissileff H.R, Pi-Sunyer F.X, Thornton J& Smith G.P. 1981C-terminal octapeptide of cholecystokinin decreases food intake in man. Am. J. Clin. Nutr. 34, 154–160. Crossref, PubMed, ISI, Google Scholar
    • Kissileff H.R, Carretta J.C, Geliebter A& Pi-Sunyer F.X. 2003Cholecystokinin and stomach distension combine to reduce food intake in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R992–R998. Crossref, PubMed, ISI, Google Scholar
    • Koda S, et al.2005The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology. 146, 2369–2375.doi:10.1210/en.2004-1266. . Crossref, PubMed, ISI, Google Scholar
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H& Kangawa K. 1999Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 402, 656–660.doi:10.1038/45230. . Crossref, PubMed, ISI, Google Scholar
    • Konturek S.J, Popiela T, Slowiaczek M& Bielanski W. 1987Gastric acid and pancreatic polypeptide responses to modified sham feeding. Effects of truncal and parietal cell vagotomy. Gut. 28, 280–286. Crossref, PubMed, ISI, Google Scholar
    • Korbonits M, Goldstone A.P, Gueorguiev M& Grossman A.B. 2004Ghrelin—a hormone with multiple functions. Front. Neuroendocrinol. 25, 27–68.doi:10.1016/j.yfrne.2004.03.002. . Crossref, PubMed, ISI, Google Scholar
    • Korner J, Bessler M, Cirilo L.J, Conwell I.M, Daud A, Restuccia N.L& Wardlaw S.L. 2005Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J. Clin. Endocrinol. Metab. 90, 359–365.doi:10.1210/jc.2004-1076. . Crossref, PubMed, ISI, Google Scholar
    • Kreymann B, Williams G, Ghatei M.A& Bloom S.R. 1987Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 2, 1300–1304.doi:10.1016/S0140-6736(87)91194-9. . Crossref, PubMed, ISI, Google Scholar
    • Kreymann B, Ghatei M.A, Burnet P, Williams G, Kanse S, Diani A.R& Bloom S.R. 1989Characterization of glucagon-like peptide-1-(7-36)amide in the hypothalamus. Brain Res. 502, 325–331.doi:10.1016/0006-8993(89)90628-8. . Crossref, PubMed, ISI, Google Scholar
    • Lachey J.L, D'Alessio D.A, Rinaman L, Elmquist J.K, Drucker D.J& Seeley R.J. 2005The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology. 146, 458–462.doi:10.1210/en.2004-0419. . Crossref, PubMed, ISI, Google Scholar
    • Larsen P.J& Kristensen P. 1997The neuropeptide Y (Y4) receptor is highly expressed in neurones of the rat dorsal vagal complex. Brain Res. Mol. Brain Res. 48, 1–6.doi:10.1016/S0169-328X(97)00069-7. . Crossref, PubMed, Google Scholar
    • Larsen P.J, Tang-Christensen M, Holst J.J& Orskov CDistribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience. 77, 1997a257–270.doi:10.1016/S0306-4522(96)00434-4. . Crossref, PubMed, ISI, Google Scholar
    • Larsen P.J, Tang-Christensen M& Jessop D.SCentral administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology. 138, 1997b4445–4455.doi:10.1210/en.138.10.4445. . Crossref, PubMed, ISI, Google Scholar
    • Larsson L.I, Sundler F& Hakanson R. 1975Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tissue Res. 156, 167–171.doi:10.1007/BF00221800. . Crossref, PubMed, ISI, Google Scholar
    • Lassmann V, Vague P, Vialettes B& Simon M.C. 1980Low plasma levels of pancreatic polypeptide in obesity. Diabetes. 29, 428–430. Crossref, PubMed, ISI, Google Scholar
    • Le Quellec A, Kervran A, Blache P, Ciurana A.J& Bataille D. 1992Oxyntomodulin-like immunoreactivity: diurnal profile of a new potential enterogastrone. J. Clin. Endocrinol. Metab. 74, 1405–1409.doi:10.1210/jc.74.6.1405. . PubMed, ISI, Google Scholar
    • Le Roux C.W, Ghatei M.A, Gibbs J.S& Bloom S.R. 2005The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart. 91, 241–242.doi:10.1136/hrt.2003.026880. . Crossref, PubMed, ISI, Google Scholar
    • Levine A.S& Morley J.E. 1982Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism. Pharmacol. Biochem. Behav. 16, 897–902.doi:10.1016/0091-3057(82)90041-7. . Crossref, PubMed, ISI, Google Scholar
    • Liddle R.A, Goldfine I.D, Rosen M.S, Taplitz R.A& Williams J.A. 1985Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J. Clin. Invest. 75, 1144–1152. Crossref, PubMed, ISI, Google Scholar
    • Lieverse R.J, Jansen J.B, van de Z.A, Samson L, Masclee A.A& Lamers C.B. 1993Effects of a physiological dose of cholecystokinin on food intake and postprandial satiation in man. Regul. Pept. 43, 83–89.doi:10.1016/0167-0115(93)90410-A. . Crossref, PubMed, Google Scholar
    • Lin H.C& Chey W.Y. 2003Cholecystokinin and peptide YY are released by fat in either proximal or distal small intestine in dogs. Regul. Pept. 114, 131–135.doi:10.1016/S0167-0115(03)00115-0. . Crossref, PubMed, Google Scholar
    • Lin H.C& Taylor I.L. 2004Release of peptide YY by fat in the proximal but not distal gut depends on an atropine-sensitive cholinergic pathway. Regul. Pept. 117, 73–76.doi:10.1016/j.regpep.2003.10.008. . Crossref, PubMed, Google Scholar
    • Liu M, Doi T, Shen L, Woods S.C, Seeley R.J, Zheng S, Jackman A& Tso P. 2001Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1382–R1387. Crossref, PubMed, ISI, Google Scholar
    • Liu M, Shen L, Doi T, Woods S.C, Seeley R.J& Tso P. 2003Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain Res. 971, 232–238.doi:10.1016/S0006-8993(03)02402-8. . Crossref, PubMed, ISI, Google Scholar
    • Lotter E.C, Krinsky R, McKay J.M, Treneer C.M, Porter D& Woods S.C. 1981Somatostatin decreases food intake of rats and baboons. J. Comp. Physiol. Psychol. 95, 278–287. Crossref, PubMed, ISI, Google Scholar
    • Ludvik B, Kautzky-Willer A, Prager R, Thomaseth K& Pacini G. 1997Amylin: history and overview. Diab. Med. 14, Suppl. 2, S9–S13.doi:10.1002/(SICI)1096-9136(199706)14:2+<S9::AID-DIA397>3.3.CO;2-4. . Crossref, PubMed, ISI, Google Scholar
    • Lundell I, Blomqvist A.G, Berglund M.M, Schober D.A, Johnson D, Statnick M.A, Gadski R.A, Gehlert D.R& Larhammar D. 1995Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270, 29 123–29 128.doi:10.1074/jbc.270.49.29123. . Crossref, ISI, Google Scholar
    • Lutz T.A, Del P.E& Scharrer E. 1994Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol. Behav. 55, 891–895.doi:10.1016/0031-9384(94)90076-0. . Crossref, PubMed, ISI, Google Scholar
    • Lutz T.A, Del P.E& Scharrer E. 1995Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin. Peptides. 16, 457–462.doi:10.1016/0196-9781(94)00203-I. . Crossref, PubMed, ISI, Google Scholar
    • Malaisse-Lagae F, Carpentier J.L, Patel Y.C, Malaisse W.J& Orci L. 1977Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis. Experientia. 33, 915–917.doi:10.1007/BF01951279. . Crossref, PubMed, Google Scholar
    • Matson C.A, Reid D.F, Cannon T.A& Ritter R.C. 2000Cholecystokinin and leptin act synergistically to reduce body weight. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R882–R890. Crossref, PubMed, ISI, Google Scholar
    • McLaughlin C.L, Baile C.A& Buonomo F.C. 1985Effect of CCK antibodies on food intake and weight gain in Zucker rats. Physiol. Behav. 34, 277–282.doi:10.1016/0031-9384(85)90116-7. . Crossref, PubMed, ISI, Google Scholar
    • Meeran K, et al.1999Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Endocrinology. 140, 244–250.doi:10.1210/en.140.1.244. . Crossref, PubMed, ISI, Google Scholar
    • Meereis-Schwanke K, Klonowski-Stumpe H, Herberg L& Niederau C. 1998Long-term effects of CCK-agonist and -antagonist on food intake and body weight in Zucker lean and obese rats. Peptides. 19, 291–299.doi:10.1016/S0196-9781(97)00261-1. . Crossref, PubMed, ISI, Google Scholar
    • Meguro T, Shimosegawa T, Kikuchi Y, Koizumi M& Toyota T. 1995Effects of cisapride on gallbladder emptying and pancreatic polypeptide and cholecystokinin release in humans. J. Gastroenterol. 30, 237–243.doi:10.1007/BF02348671. . Crossref, PubMed, ISI, Google Scholar
    • Meier J.J, Nauck M.A, Schmidt W.E& Gallwitz B. 2002Gastric inhibitory polypeptide: the neglected incretin revisited. Regul. Pept. 107, 1–13.doi:10.1016/S0167-0115(02)00039-3. . Crossref, PubMed, Google Scholar
    • Meryn S, Stein D& Straus E.W. 1986Fasting- and meal-stimulated peptide hormone concentrations before and after gastric surgery for morbid obesity. Metabolism. 35, 798–802.doi:10.1016/0026-0495(86)90218-0. . Crossref, PubMed, ISI, Google Scholar
    • Michel M.C, Beck-Sickinger A, Cox H, Doods H.N, Herzog H, Larhammar D, Quirion R, Schwartz T& Westfall T. 1998XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50, 143–150. PubMed, ISI, Google Scholar
    • Miyasaka K, et al.2002Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze. Neurosci. Lett. 335, 115–118.doi:10.1016/S0304-3940(02)01176-X. . Crossref, PubMed, ISI, Google Scholar
    • Mochiki E, Inui A, Satoh M, Mizumoto A& Itoh Z. 1997Motilin is a biosignal controlling cyclic release of pancreatic polypeptide via the vagus in fasted dogs. Am. J. Physiol. 272, G224–G232. PubMed, ISI, Google Scholar
    • Mojsov S, Heinrich G, Wilson I.B, Ravazzola M, Orci L& Habener J.F. 1986Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J. Biol. Chem. 261, 11 880–11 889. Crossref, ISI, Google Scholar
    • Mojsov S, Weir G.C& Habener J.F. 1987Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79, 616–619. Crossref, PubMed, ISI, Google Scholar
    • Montrose-Rafizadeh C, Yang H, Wang Y, Roth J, Montrose M.H& Adams L.G. 1997Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J. Cell. Physiol. 172, 275–283.doi:10.1002/(SICI)1097-4652(199709)172:3<275::AID-JCP1>3.0.CO;2-L. . Crossref, PubMed, ISI, Google Scholar
    • Moran T.H& Kinzig K.P. 2004Gastrointestinal satiety signals II. Cholecystokinin. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G183–G188.doi:10.1152/ajpgi.00434.2003. . Crossref, PubMed, ISI, Google Scholar
    • Moran T.H& McHugh P.R. 1982Cholecystokinin suppresses food intake by inhibiting gastric emptying. Am. J. Physiol. 242, R491–R497. PubMed, ISI, Google Scholar
    • Moran T.H& McHugh P.R. 1988Gastric and nongastric mechanisms for satiety action of cholecystokinin. Am. J. Physiol. 254, R628–R632. PubMed, ISI, Google Scholar
    • Moran T.H, Ameglio P.J, Schwartz G.J& McHugh P.R. 1992Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am. J. Physiol. 262, R46–R50. PubMed, ISI, Google Scholar
    • Moran T.H, Katz L.F, Plata-Salaman C.R& Schwartz G.J. 1998Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am. J. Physiol. 274, R618–R625. PubMed, Google Scholar
    • Moran T.H, Smedh U, Kinzig K.P, Scott K.A, Knipp S& Ladenheim E.E. 2005Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R384–R388. Crossref, PubMed, ISI, Google Scholar
    • Morisset J, Wong H, Walsh J.H, Laine J& Bourassa J. 2000Pancreatic CCK(B) receptors: their potential roles in somatostatin release and delta-cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G148–G156. Crossref, PubMed, ISI, Google Scholar
    • Morley J.E, Levine A.S, Yamada T, Gebhard R.L, Prigge W.F, Shafer R.B, Goetz F.C& Silvis S.E. 1983Effect of exorphins on gastrointestinal function, hormonal release, and appetite. Gastroenterology. 84, 1517–1523. Crossref, PubMed, ISI, Google Scholar
    • Morley J.E, Levine A.S, Grace M& Kneip J. 1985Peptide YY (PYY), a potent orexigenic agent. Brain Res. 341, 200–203.doi:10.1016/0006-8993(85)91490-8. . Crossref, PubMed, ISI, Google Scholar
    • Morton G.J, Blevins J.E, Williams D.L, Niswender K.D, Gelling R.W, Rhodes C.J, Baskin D.G& Schwartz M.W. 2005Leptin action in the forebrain regulates the hindbrain response to satiety signals. J. Clin. Invest. 115, 703–710.doi:10.1172/JCI200522081. . Crossref, PubMed, ISI, Google Scholar
    • Mullins D.E, Zhang X& Hawes B.E. 2002Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes. Regul. Pept. 105, 65–73.doi:10.1016/S0167-0115(01)00388-3. . Crossref, PubMed, Google Scholar
    • Munroe D.G, et al.1999Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl Acad. Sci. USA. 96, 1569–1573.doi:10.1073/pnas.96.4.1569. . Crossref, PubMed, ISI, Google Scholar
    • Nagaya N, et al.2004Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation. 110, 3674–3679.doi:10.1161/01.CIR.0000149746.62908.BB. . Crossref, PubMed, ISI, Google Scholar
    • Naslund E, Barkeling B, King N, Gutniak M, Blundell J.E, Holst J.J, Rossner S& Hellstrom P.MEnergy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men. Int. J. Obes. Relat. Metab. Disord. 23, 1999a304–311.doi:10.1038/sj.ijo.0800818. . Crossref, PubMed, ISI, Google Scholar
    • Naslund E, Bogefors J, Skogar S, Gryback P, Jacobsson H, Holst J.J& Hellstrom P.MGLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am. J. Physiol. 277, 1999bR910–R916. PubMed, Google Scholar
    • Naslund E, King N, Mansten S, Adner N, Holst J.J, Gutniak M& Hellstrom P.M. 2004Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects. Br. J. Nutr. 91, 439–446.doi:10.1079/BJN20031064. . Crossref, PubMed, ISI, Google Scholar
    • Neary N.M, et al.2004Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J. Clin. Endocrinol. Metab. 89, 2832–2836.doi:10.1210/jc.2003-031768. . Crossref, PubMed, ISI, Google Scholar
    • Niebel W, Eysselein V.E& Singer M.V. 1987Pancreatic polypeptide response to a meal before and after cutting the extrinsic nerves of the upper gastrointestinal tract and the pancreas in the dog. Dig. Dis. Sci. 32, 1004–1009.doi:10.1007/BF01297191. . Crossref, PubMed, ISI, Google Scholar
    • Nikolaidis L.A, Mankad S, Sokos G.G, Miske G, Shah A, Elahi D& Shannon R.P. 2004Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation. 109, 962–965.doi:10.1161/01.CIR.0000120505.91348.58. . Crossref, PubMed, ISI, Google Scholar
    • Nilaver G, Beinfeld M.C, Bond C.T, Daikh D, Godfrey B& Adelman J.P. 1988Heterogeneity of motilin immunoreactivity in mammalian tissue. Synapse. 2, 266–275.doi:10.1002/syn.890020315. . Crossref, PubMed, ISI, Google Scholar
    • O'Donohue T.L, et al.1981Identification, characterization and distribution of motilin immunoreactivity in the rat central nervous system. Peptides. 2, 467–477. Crossref, PubMed, ISI, Google Scholar
    • Okumura T, Fukagawa K, Tso P, Taylor I.L& Pappas T.N. 1996Apolipoprotein A-IV acts in the brain to inhibit gastric emptying in the rat. Am. J. Physiol. 270, G49–G53. PubMed, ISI, Google Scholar
    • Olson R.D, Kastin A.J, von Almen T.K, Coy D.H& Olson G.A. 1980Systemic injections of gastro-intestinal peptides alter behavior in rats. Peptides. 1, 383–385.doi:10.1016/0196-9781(80)90018-2. . Crossref, PubMed, ISI, Google Scholar
    • Olszewski P.K, Wirth M.M, Shaw T.J, Grace M.K& Levine A.S. 2003Peptides that regulate food intake: effect of peptide histidine isoleucine on consummatory behavior in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R1445–R1453. Crossref, PubMed, ISI, Google Scholar
    • Onaga T, Zabielski R& Kato S. 2002Multiple regulation of peptide YY secretion in the digestive tract. Peptides. 23, 279–290.doi:10.1016/S0196-9781(01)00609-X. . Crossref, PubMed, ISI, Google Scholar
    • Orskov C, Rabenhoj L, Wettergren A, Kofod H& Holst J.JTissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes. 43, 1994a535–539. Crossref, PubMed, ISI, Google Scholar
    • Orskov C, Rabenhoj L, Wettergren A, Kofod H& Holst J.JTissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes. 43, 1994b535–539. Crossref, PubMed, ISI, Google Scholar
    • Orskov C, Poulsen S.S, Moller M& Holst J.J. 1996Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes. 45, 832–835. Crossref, PubMed, ISI, Google Scholar
    • Parker R.M& Herzog H. 1999Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur. J. Neurosci. 11, 1431–1448.doi:10.1046/j.1460-9568.1999.00553.x. . Crossref, PubMed, ISI, Google Scholar
    • Peruzzo B, Pastor F.E, Blazquez J.L, Schobitz K, Pelaez B, Amat P& Rodriguez E.M. 2000A second look at the barriers of the medial basal hypothalamus. Exp. Brain Res. 132, 10–26.doi:10.1007/s002219900289. . Crossref, PubMed, ISI, Google Scholar
    • Peters J.H, McKay B.M, Simasko S.M& Ritter R.C. 2005Leptin-induced satiation mediated by abdominal vagal afferents. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R879–R884. Crossref, PubMed, ISI, Google Scholar
    • Pittner R.A, et al.2004Effects of PYY[3-36] in rodent models of diabetes and obesity. Int. J. Obes. Relat. Metab. Disord. 28, 963–971.doi:10.1038/sj.ijo.0802696. . Crossref, PubMed, ISI, Google Scholar
    • Rehfeld J.F. 1998How to measure cholecystokinin in tissue, plasma and cerebrospinal fluid. Regul. Pept. 78, 31–39.doi:10.1016/S0167-0115(98)00133-5. . Crossref, PubMed, Google Scholar
    • Rehfeld J.F. 2004Clinical endocrinology and metabolism. Cholecystokinin. Best Pract. Res. Clin. Endocrinol. Metab. 18, 569–586.doi:10.1016/j.beem.2004.07.002. . Crossref, PubMed, ISI, Google Scholar
    • Rehfeld J.F, Sun G, Christensen T& Hillingso J.G. 2001The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J. Clin. Endocrinol. Metab. 86, 251–258.doi:10.1210/jc.86.1.251. . PubMed, ISI, Google Scholar
    • Rehfeld J.F, Bungaard J.R, Friis-Hansen L& Goetze J.P. 2003On the tissue-specific processing of procholecystokinin in the brain and gut—a short review. J. Physiol. Pharmacol. 54, Suppl. 4, 73–79. PubMed, Google Scholar
    • Reichlin S. 1983Somatostatin. N. Engl. J. Med. 309, 1495–1501. Crossref, PubMed, ISI, Google Scholar
    • Roberge J.N& Brubaker P.L. 1991Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients. Endocrinology. 128, 3169–3174. Crossref, PubMed, ISI, Google Scholar
    • Rocca A.S& Brubaker P.L. 1999Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology. 140, 1687–1694.doi:10.1210/en.140.4.1687. . Crossref, PubMed, ISI, Google Scholar
    • Rosenfeld D.J& Garthwaite T.L. 1987Central administration of motilin stimulates feeding in rats. Physiol. Behav. 39, 753–756.doi:10.1016/0031-9384(87)90261-7. . Crossref, PubMed, ISI, Google Scholar
    • Rowland N.E, Crews E.C& Gentry R.M. 1997Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul. Pept. 71, 171–174.doi:10.1016/S0167-0115(97)01034-3. . Crossref, PubMed, Google Scholar
    • Rushing P.A, Hagan M.M, Seeley R.J, Lutz T.A& Woods S.C. 2000Amylin: a novel action in the brain to reduce body weight. Endocrinology. 141, 850–853.doi:10.1210/en.141.2.850. . Crossref, PubMed, ISI, Google Scholar
    • Sanjuan J, Toirac I, Gonzalez J.C, Leal C, Molto M.D, Najera C& De F.R. 2004A possible association between the CCK-AR gene and persistent auditory hallucinations in schizophrenia. Eur. Psychiatry. 19, 349–353. Crossref, PubMed, ISI, Google Scholar
    • Sarson D.L, Scopinaro N& Bloom S.R. 1981Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity. Int. J. Obes. 5, 471–480. PubMed, ISI, Google Scholar
    • Schepp W, Dehne K, Riedel T, Schmidtler J, Schaffer K& Classen M. 1996Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2. Digestion. 57, 398–405. Crossref, PubMed, ISI, Google Scholar
    • Schjoldager B.T, Baldissera F.G, Mortensen P.E, Holst J.J& Christiansen J. 1988Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. Eur. J. Clin. Invest. 18, 499–503. Crossref, PubMed, ISI, Google Scholar
    • Schjoldager B, Mortensen P.E, Myhre J, Christiansen J& Holst J.J. 1989Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions. Dig. Dis. Sci. 34, 1411–1419.doi:10.1007/BF01538078. . Crossref, PubMed, ISI, Google Scholar
    • Schmidt W.E, Siegel E.G& Creutzfeldt W. 1985Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia. 28, 704–707.doi:10.1007/BF00291980. . Crossref, PubMed, ISI, Google Scholar
    • Schmidt P.T, Naslund E, Gryback P, Jacobsson H, Hartmann B, Holst J.J& Hellstrom P.M. 2003Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regul. Pept. 116, 21–25.doi:10.1016/S0167-0115(03)00175-7. . Crossref, PubMed, Google Scholar
    • Schmidt P.T, Naslund E, Gryback P, Jacobsson H, Holst J.J, Hilsted L& Hellstrom P.M. 2005A role for pancreatic polypeptide in the regulation of gastric emptying and short term metabolic control. J. Clin. Endocrinol. Metab. 90, 5241–5246.doi:10.1210/jc.2004-2089. . Crossref, PubMed, ISI, Google Scholar
    • Schwartz G.J, Whitney A, Skoglund C, Castonguay T.W& Moran T.H. 1999Decreased responsiveness to dietary fat in Otsuka Long–Evans Tokushima fatty rats lacking CCK-A receptors. Am. J. Physiol. 277, R1144–R1151. PubMed, Google Scholar
    • Schwartz M.W, Woods S.C, Porte D, Seeley R.J& Baskin D.G. 2000Central nervous system control of food intake. Nature. 404, 661–671. Crossref, PubMed, ISI, Google Scholar
    • Scott R.B, Kirk D, MacNaughton W.K& Meddings J.B. 1998GLP-2 augments the adaptive response to massive intestinal resection in rat. Am. J. Physiol. 275, G911–G921. PubMed, Google Scholar
    • Scott V, Kimura N, Stark J.A& Luckman S.M. 2005Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour. J. Neuroendocrinol. 17, 452–457.doi:10.1111/j.1365-2826.2005.01330.x. . Crossref, PubMed, ISI, Google Scholar
    • Scrocchi L.A, Brown T.J, MaClusky N, Brubaker P.L, Auerbach A.B, Joyner A.L& Drucker D.J. 1996Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2, 1254–1258.doi:10.1038/nm1196-1254. . Crossref, PubMed, ISI, Google Scholar
    • Seeley R.J, Blake K, Rushing P.A, Benoit S, Eng J, Woods S.C& D'Alessio D. 2000The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J. Neurosci. 20, 1616–1621. Crossref, PubMed, ISI, Google Scholar
    • Service G.J, Thompson G.B, Service F.J, Andrews J.C, Collazo-Clavell M.L& Lloyd R.V. 2005Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N. Engl. J. Med. 353, 249–254.doi:10.1056/NEJMoa043690. . Crossref, PubMed, ISI, Google Scholar
    • Shughrue P.J, Lane M.V& Merchenthaler I. 1996Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus. Endocrinology. 137, 5159–5162.doi:10.1210/en.137.11.5159. . Crossref, PubMed, ISI, Google Scholar
    • Silva A.P, Bethmann K, Raulf F& Schmid H.A. 2005Regulation of ghrelin secretion by somatostatin analogs in rats. Eur. J. Endocrinol. 152, 887–894.doi:10.1530/eje.1.01914. . Crossref, PubMed, ISI, Google Scholar
    • Smith-White M.A, Hardy T.A, Brock J.A& Potter E.K. 2001Effects of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246, on Y2 receptors at peripheral neuroeffector junctions. Br. J. Pharmacol. 132, 861–868.doi:10.1038/sj.bjp.0703879. . Crossref, PubMed, ISI, Google Scholar
    • Talsania T, Anini Y, Siu S, Drucker D.J& Brubaker P.L. 2005Peripheral exendin-4 and peptide YY3-36 synergistically reduce food intake through different mechanisms in mice. Endocrinology. 146, 3748–3756.doi:10.1210/en.2005-0473. . Crossref, PubMed, ISI, Google Scholar
    • Tang-Christensen M, Larsen P.J, Thulesen J, Romer J& Vrang N. 2000The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat. Med. 6, 802–807.doi:10.1038/77535. . Crossref, PubMed, ISI, Google Scholar
    • Tang-Christensen M, Vrang N& Larsen P.J. 2001Glucagon-like peptide containing pathways in the regulation of feeding behaviour. Int. J. Obes. Relat. Metab. Disord. 25, Suppl. 5, S42–S47. Crossref, PubMed, ISI, Google Scholar
    • Tatemoto K. 1982Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl Acad. Sci. USA. 79, 2514–2518. Crossref, PubMed, ISI, Google Scholar
    • Ter Horst G.J, de Boer P, Luiten P.G& van Willigen J.D. 1989Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat. Neuroscience. 31, 785–797.doi:10.1016/0306-4522(89)90441-7. . Crossref, PubMed, ISI, Google Scholar
    • Thorens B. 1992Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc. Natl Acad. Sci. USA. 89, 8641–8645. Crossref, PubMed, ISI, Google Scholar
    • Thorens B, Porret A, Buhler L, Deng S.P, Morel P& Widmann C. 1993Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 42, 1678–1682. Crossref, PubMed, ISI, Google Scholar
    • Tolessa T, Gutniak M, Holst J.J, Efendic S& Hellstrom P.M. 1998Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin. J. Clin. Invest. 102, 764–774. Crossref, PubMed, ISI, Google Scholar
    • Track N.S, McLeod R.S& Mee A.V. 1980Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations. Can. J. Physiol. Pharmacol. 58, 1484–1489. Crossref, PubMed, ISI, Google Scholar
    • Tschop M, Smiley D.L& Heiman M.L. 2000Ghrelin induces adiposity in rodents. Nature. 407, 908–913. Crossref, PubMed, ISI, Google Scholar
    • Tschop M, Weyer C, Tataranni P.A, Devanarayan V, Ravussin E& Heiman M.L. 2001Circulating ghrelin levels are decreased in human obesity. Diabetes. 50, 707–709. Crossref, PubMed, ISI, Google Scholar
    • Tschop M, et al.2004Physiology: does gut hormone PYY3-36 decrease food intake in rodents?. Nature. 430, doi:101038/nature02665. . Crossref, PubMed, ISI, Google Scholar
    • Turton M.D, et al.1996A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 379, 69–72.doi:10.1038/379069a0. . Crossref, PubMed, ISI, Google Scholar
    • Uhe A.M, Szmukler G.I, Collier G.R, Hansky J, O'Dea K& Young G.P. 1992Potential regulators of feeding behavior in anorexia nervosa. Am. J. Clin. Nutr. 55, 28–32. Crossref, PubMed, ISI, Google Scholar
    • Usellini L, Buchan A.M, Polak J.M, Capella C, Cornaggia M& Solcia E. 1984Ultrastructural localization of motilin in endocrine cells of human and dog intestine by the immunogold technique. Histochemistry. 81, 363–368.doi:10.1007/BF00514330. . Crossref, PubMed, Google Scholar
    • van der Kooy D, Koda L.Y, McGinty J.F, Gerfen C.R& Bloom F.E. 1984The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J. Comp. Neurol. 224, 1–24.doi:10.1002/cne.902240102. . Crossref, PubMed, ISI, Google Scholar
    • van der Lely A.J, Tschop M, Heiman M.L& Ghigo E. 2004Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 25, 426–457.doi:10.1210/er.2002-0029. . Crossref, PubMed, ISI, Google Scholar
    • van Dijk G, Thiele T.E, Donahey J.C, Campfield L.A, Smith F.J, Burn P, Bernstein I.L, Woods S.C& Seeley R.J. 1996Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271, R1096–R1100. PubMed, Google Scholar
    • Verdich C, et al.A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J. Clin. Endocrinol. Metab. 86, 2001a4382–4389.doi:10.1210/jc.86.9.4382. . PubMed, ISI, Google Scholar
    • Verdich C, Toubro S, Buemann B, Lysgard M.J, Juul H.J& Astrup AThe role of postprandial releases of insulin and incretin hormones in meal-induced satiety—effect of obesity and weight reduction. Int. J. Obes. Relat. Metab. Disord. 25, 2001b1206–1214.doi:10.1038/sj.ijo.0801655. . Crossref, PubMed, ISI, Google Scholar
    • Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul A.G& Holst J.J. 2003Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 88, 2706–2713.doi:10.1210/jc.2002-021873. . Crossref, PubMed, ISI, Google Scholar
    • Wank S.A. 1995Cholecystokinin receptors. Am. J. Physiol. 269, G628–G646. PubMed, ISI, Google Scholar
    • Wei Y& Mojsov S. 1995Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 358, 219–224.doi:10.1016/0014-5793(94)01430-9. . Crossref, PubMed, ISI, Google Scholar
    • West D.B, Fey D& Woods S.C. 1984Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am. J. Physiol. 246, R776–R787. PubMed, ISI, Google Scholar
    • West D.B, Greenwood M.R, Marshall K.A& Woods S.CLithium chloride, cholecystokinin and meal patterns: evidence that cholecystokinin suppresses meal size in rats without causing malaise. Appetite. 8, 1987a221–227.doi:10.1016/0195-6663(87)90021-3. . Crossref, PubMed, ISI, Google Scholar
    • West D.B, Greenwood M.R, Sullivan A.C, Prescod L, Marzullo L.R& Triscari JInfusion of cholecystokinin between meals into free-feeding rats fails to prolong the intermeal interval. Physiol. Behav. 39, 1987b111–115.doi:10.1016/0031-9384(87)90407-0. . Crossref, PubMed, ISI, Google Scholar
    • Wettergren A, Maina P, Boesby S& Holst J.J. 1997Glucagon-like peptide-1 7-36 amide and peptide YY have additive inhibitory effect on gastric acid secretion in man. Scand. J. Gastroenterol. 32, 552–555. Crossref, PubMed, ISI, Google Scholar
    • Wheeler M.B, Gelling R.W, McIntosh C.H, Georgiou J, Brown J.C& Pederson R.A. 1995Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties. Endocrinology. 136, 4629–4639.doi:10.1210/en.136.10.4629. . Crossref, PubMed, ISI, Google Scholar
    • Whitcomb D.C, Taylor I.L& Vigna S.R. 1990Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am. J. Physiol. 259, G687–G691. PubMed, ISI, Google Scholar
    • Wisen O, Bjorvell H, Cantor P, Johansson C& Theodorsson E. 1992Plasma concentrations of regulatory peptides in obesity following modified sham feeding (MSF) and a liquid test meal. Regul. Pept. 39, 43–54.doi:10.1016/0167-0115(92)90007-H. . Crossref, PubMed, Google Scholar
    • Woods S.C, West D.B, Stein L.J, McKay L.D, Lotter E.C, Porte S.G, Kenney N.J& Porte D. 1981Peptides and the control of meal size. Diabetologia. 20, 305–313.doi:10.1007/BF00254497. . Crossref, ISI, Google Scholar
    • Wren A.M, Seal L.J, Cohen M.A, Brynes A.E, Frost G.S, Murphy K.G, Dhillo W.S, Ghatei M.A& Bloom S.RGhrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 2001a5992doi:10.1210/jc.86.12.5992. . Crossref, PubMed, ISI, Google Scholar
    • Wren A.M, et al.Ghrelin causes hyperphagia and obesity in rats. Diabetes. 50, 2001b2540–2547. Crossref, PubMed, ISI, Google Scholar
    • Wynne K, et al.Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial. J. Am. Soc. Nephrol. 16, 2005a2111–2118.doi:10.1681/ASN.2005010039. . Crossref, PubMed, ISI, Google Scholar
    • Wynne K, et al.Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes. 54, 2005b2390–2395. Crossref, PubMed, ISI, Google Scholar
    • Xiao Q, Boushey R.P, Drucker D.J& Brubaker P.L. 1999Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans. Gastroenterology. 117, 99–105.doi:10.1016/S0016-5085(99)70555-X. . Crossref, PubMed, ISI, Google Scholar
    • Yamamoto H, et al.2002Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J. Clin. Invest. 110, 43–52.doi:10.1172/JCI200215595. . Crossref, PubMed, ISI, Google Scholar
    • Yang H, Egan J.M, Wang Y, Moyes C.D, Roth J, Montrose M.H& Montrose-Rafizadeh C. 1998GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am. J. Physiol. 275, C675–C683. Crossref, PubMed, Google Scholar
    • Yusta B, Huang L, Munroe D, Wolff G, Fantaske R, Sharma S, Demchyshyn L, Asa S.L& Drucker D.J. 2000Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology. 119, 744–755.doi:10.1053/gast.2000.16489. . Crossref, PubMed, ISI, Google Scholar
    • Zachrisson O, de B.J, Wendt K.R, Hirsch S& Lindefors N. 1999Cholecystokinin CCK(B) receptor mRNA isoforms: expression in schizophrenic brains. Neuroreport. 10, 3265–3268. Crossref, PubMed, ISI, Google Scholar
    • Zipf W.B, O'Dorisio T.M, Cataland S& Sotos J. 1981Blunted pancreatic polypeptide responses in children with obesity of Prader–Willi syndrome. J. Clin. Endocrinol. Metab. 52, 1264–1266. Crossref, PubMed, ISI, Google Scholar
    • Zittel T.T, Glatzle J, Kreis M.E, Starlinger M, Eichner M, Raybould H.E, Becker H.D& Jehle E.C. 1999C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats. Brain Res. 846, 1–11.doi:10.1016/S0006-8993(99)01842-9. . Crossref, PubMed, ISI, Google Scholar
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