Synthesis of mesoporous silicate molecular sieves by the aerosol-assisted method for loading and release of drug

The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N2 adsorption–desorption isotherms. The drug IBU was applied as a model drug to investigate the drug release behaviour by ultraviolet spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by the aerosol-assisted method are spherical with a core–shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. It exhibits safety to a certain degree. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.

The issues in the manuscript are listed as below: 1.
Introduction, the design of drug delivery systems based on mesoporous silicate had been investigated wildly in the field of biomedical, and some relative works must be cited to enrich the background of this paper. Please see references ( The FT-IR and XPS characterization of mesoporous silicate molecular sieves could be presented, if possible? Please see (Advanced Science 5 (2018) 1800510; Biomaterials Science 6 (2018) 1084-1098). 3.
The of Figure 6 should be checked and corrected. 4.
How many times of ibuprofen release from mesoporous silicate molecular sieves? The standard deviation should be shown. 5.
The bio-safety of mesoporous silicate molecular sieves could be evaluated, if possible? 6.
Overall the paper is easily read, but there are still some minor problems in language and spelling. A throughout checking is recommended. The manuscript could be considered for publication only after revision. Moreover, I am glad to review a revision of this manuscript if necessary.

Decision letter (RSOS-200650.R0)
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Dear Dr Hao:
Title: Synthesis of novel mesoporous silicate molecular sieves by Aerosol-assisted method for loading and release of drug Manuscript ID: RSOS-200650 Thank you for submitting the above manuscript to Royal Society Open Science. On behalf of the Editors and the Royal Society of Chemistry, I am pleased to inform you that your manuscript will be accepted for publication in Royal Society Open Science subject to minor revision in accordance with the referee suggestions. Please find the reviewers' comments at the end of this email. I apologise that this has taken longer than usual.
The reviewers and handling editors have recommended publication, but also suggest some minor revisions to your manuscript. Therefore, I invite you to respond to the comments and revise your manuscript.
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RSC Associate Editor:
Comments to the Author: The aerosol-assisted method were reported for the preparation of mesoporous silicate molecular sieves with detail morphological and structural characterization details. ********************************************** Reviewer comments to Author: Reviewer: 1 Comments to the Author(s) In this article, the authors report the aerosol-assisted synthesis of spherical mesoporous silicate molecular sieves with sustained ibuprofen release performance. The presented gas-phase process may address the limitations of conventional wet chemistry-based routes. The work lies well in the scope of the Royal Society Open Science. The results are significant and might attract broad interest. I thus recommend it for publication after minor revisions addressed as follows. This manuscript from Liang Hao and coworkers is reporting a good work about the novel mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by aerosol-assisted method for loading and release of ibuprofen. The synthesized samples were characterized adequately. The results suggested the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers. This study is an interesting work for design novel mesoporous silicate molecular sieves for drug delivery. I would like to recommend the publication of this work after revision. However, the authors should solve the following issues. The issues in the manuscript are listed as below: 1. Introduction, the design of drug delivery systems based on mesoporous silicate had been investigated wildly in the field of biomedical, and some relative works must be cited to enrich the background of this paper. Please see references ( Figure 6 should be checked and corrected. 4. How many times of ibuprofen release from mesoporous silicate molecular sieves? The standard deviation should be shown. 5. The bio-safety of mesoporous silicate molecular sieves could be evaluated, if possible? 6. Overall the paper is easily read, but there are still some minor problems in language and spelling. A throughout checking is recommended.

Comments to the Author(s)
The revised manuscript has been improved greatly and it could be accepted for publication.

Decision letter (RSOS-200650.R1)
We hope you are keeping well at this difficult and unusual time. We continue to value your support of the journal in these challenging circumstances. If Royal Society Open Science can assist you at all, please don't hesitate to let us know at the email address below. ******** RSC Associate Editor: Comments to the Author: Accept as is RSC Subject Editor: Comments to the Author: (There are no comments.) *********