Interface Focus: Vol 3, No 3

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Table of Contents

Theme Issue 'Molecular-, nano- and micro-devices for real-time in vivo sensing' organized and edited by Weian Zhao

Introduction

Introduction

Opening windows on new biology and disease mechanisms: development of real-time in vivo sensors

Mark A. Eckert and
Weian Zhao

Published:06 June 2013Article ID:20130014

https://doi.org/10.1098/rsfs.2013.0014

First Page
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References

Articles

Review article

From seeing to believing: labelling strategies for in vivo cell-tracking experiments

Fränze Progatzky,
Margaret J. Dallman and
Cristina Lo Celso

Published:06 June 2013Article ID:20130001

https://doi.org/10.1098/rsfs.2013.0001

Abstract
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Preview Abstract

Intravital microscopy has become increasingly popular over the past few decades because it provides high-resolution and real-time information about complex biological processes. Technological advances that allow deeper penetration in live tissues, such as ...

Review article

Cancer cell sensing and therapy using affinity tag-conjugated gold nanorods

Emir Yasun,
Huaizhi Kang,
Huseyin Erdal,
Sena Cansiz,
Ismail Ocsoy,
Yu-Fen Huang and
Weihong Tan

Published:06 June 2013Article ID:20130006

https://doi.org/10.1098/rsfs.2013.0006

Abstract
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Through the developments in controlling the shape of gold nanoparticles, synthesis of gold nanorods (AuNRs) can be considered as a milestone discovery in the area of nanomaterial-based cancer treatments. Besides having tuneable absorption maxima at near ...

Review article

New generation of magnetic and luminescent nanoparticles for in vivo real-time imaging

Lise-Marie Lacroix,
Fabien Delpech,
Céline Nayral,
Sébastien Lachaize and
Bruno Chaudret

Published:06 June 2013Article ID:20120103

https://doi.org/10.1098/rsfs.2012.0103

Abstract
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A new generation of optimized contrast agents is emerging, based on metallic nanoparticles (NPs) and semiconductor nanocrystals for, respectively, magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescent imaging techniques. Compared with ...

Review article

Detecting adenosine triphosphate in the pericellular space

Simonetta Falzoni,
Giovanna Donvito and
Francesco Di Virgilio

Published:06 June 2013Article ID:20120101

https://doi.org/10.1098/rsfs.2012.0101

Abstract
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Release of adenosine triphosphate (ATP) into the extracellular space occurs in response to a multiplicity of physiological and pathological stimuli in virtually all cells and tissues. A role for extracellular ATP has been identified in processes as ...

Research article

Real-time in vivo imaging of size-dependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy

Lauren M. Browning,
Tao Huang and
Xiao-Hong Nancy Xu

Published:06 June 2013Article ID:20120098

https://doi.org/10.1098/rsfs.2012.0098

Abstract
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Noble metal nanoparticles (NPs) show distinctive plasmonic optical properties and superior photostability, enabling them to serve as photostable multi-coloured optical molecular probes and sensors for real-time in vivo imaging. To effectively study ...

Research article

Silica-coated dimers of silver nanospheres as surface-enhanced Raman scattering tags for imaging cancer cells

Xiaohu Xia,
Weiyang Li,
Yu Zhang and
Younan Xia

Published:06 June 2013Article ID:20120092

https://doi.org/10.1098/rsfs.2012.0092

Abstract
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Surface-enhanced Raman scattering (SERS) tags have been actively explored as a multiplexing platform for sensitive detection of biomolecules. Here, we report a new type of SERS tags that was fabricated by sequentially functionalizing dimers made of 50 nm ...

Research article

Antisense peptide nucleic acid-functionalized cationic nanocomplex for in vivo mRNA detection

Yuefei Shen,
Ritu Shrestha,
Aida Ibricevic,
Sean P. Gunsten,
Michael J. Welch,
Karen L. Wooley,
Steven L. Brody,
John-Stephen A. Taylor and
Yongjian Liu

Published:06 June 2013Article ID:20120059

https://doi.org/10.1098/rsfs.2012.0059

Abstract
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Acute lung injury (ALI) is a complex syndrome with many aetiologies, resulting in the upregulation of inflammatory mediators in the host, followed by dyspnoea, hypoxemia and pulmonary oedema. A central mediator is inducible nitric oxide synthase (iNOS) ...

Research article

Non-aqueous microchip electrophoresis for characterization of lipid biomarkers

Larry R. Gibson and
Paul W. Bohn

Published:06 June 2013Article ID:20120096

https://doi.org/10.1098/rsfs.2012.0096

Abstract
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In vivo measurements of lipid biomarkers are hampered by their low solubility in aqueous solution, which limits the choices for molecular separations. Here, we introduce non-aqueous microchip electrophoretic separations of lipid mixtures performed in ...

Research article

Spatially selective surface platforms for binding fibrinogen prepared by particle lithography with organosilanes

Lauren E. Englade-Franklin,
ChaMarra K. Saner and
Jayne C. Garno

Published:06 June 2013Article ID:20120102

https://doi.org/10.1098/rsfs.2012.0102

Abstract
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We introduce an approach based on particle lithography to prepare spatially selective surface platforms of organosilanes that are suitable for nanoscale studies of protein binding. Particle lithography was applied for patterning fibrinogen, a plasma ...

Interface Focus cover image

06 June 2013

Volume 3Issue 3

Editor-In-Chief

Professor Russell Foster CBE FRS

About the cover

Cover image: Intravital microscopy image of fluorescent aptamer sensor-modified mesenchymal stem cells that homed to bone marrow niche. These in vivo sensors can potentially be used to visualize cellular functions and interactions in real time in living animals (work from laboratories of Dr Weian Zhao (University of California, Irvine, CA), Dr Jeffrey Karp (Brigham and Women’s Hospital, Boston, MA) and Dr Charles Lin (Massachusetts General Hospital, Boston, MA)).
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