Philosophical Transactions of the Royal Society B: Biological Sciences
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Discussion meeting issue ‘Connectome to behaviour: modelling C. elegans at cellular resolution’ organized and edited by Stephen D. Larson, Padraig Gleeson and André E.X. Brown

About the issue

An outstanding mystery in science is how cells of a brain come together to compute. Studying how this works is challenging, especially in large brains like that of humans. The worm C. elegans is one of the most exhaustively characterised animals in biology. A huge amount of experimental data has been produced by researchers on the worm’s genetics and behaviour, in addition to a complete wiring diagram of its nervous system, known as a connectome. A number of groups are attempting to consolidate this knowledge into models which can simulate its behaviour on a computer, leading to the possibility of a deeper understanding of how a complete nervous system processes information and reacts to its environment. This special issue gathers contributions from experimentalists, computational neuroscientists and engineers with a shared interest in understanding the “mind of the worm”, who are approaching this challenge from many different angles.

This issue is based on a Royal Society discussion meeting held in January 2018.


Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution
Published:10 September 2018Article ID:20170366


Review article
Clues to basis of exploratory behaviour of the C. elegans snout from head somatotropy
Published:10 September 2018Article ID:20170367

Research article
Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3
Published:10 September 2018Article ID:20170368

Review article
Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation
Published:10 September 2018Article ID:20170370

Opinion piece
Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations
Published:10 September 2018Article ID:20170371

Review article
Caenorhabditis elegans and the network control framework—FAQs
Published:10 September 2018Article ID:20170372

Research article
Signatures of proprioceptive control in Caenorhabditis elegans locomotion
Published:10 September 2018Article ID:20180208

Research article
From head to tail: a neuromechanical model of forward locomotion in Caenorhabditis elegans
Published:10 September 2018Article ID:20170374

Research article
Powerful and interpretable behavioural features for quantitative phenotyping of Caenorhabditis elegans
Published:10 September 2018Article ID:20170375

Research article
Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis
Published:10 September 2018Article ID:20170376

Research article
Functional connectomics from neural dynamics: probabilistic graphical models for neuronal network of Caenorhabditis elegans
Published:10 September 2018Article ID:20170377

Research article
c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans
Published:10 September 2018Article ID:20170379

Research article
Geppetto: a reusable modular open platform for exploring neuroscience data and models
Published:10 September 2018Article ID:20170380

Research article
Towards systematic, data-driven validation of a collaborative, multi-scale model of Caenorhabditis elegans
Published:10 September 2018Article ID:20170381

Opinion piece
OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans
Published:10 September 2018Article ID:20170382