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Philosophical Transactions of the Royal Society B: Biological Sciences

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Theo Murphy meeting ‘The virtues and vices of protein citrullination’ organized and edited by Maria A. Christophorou, Priyanka Sharma and Xuesen Zhang

Proteins within cells can be chemically modified in response to changes in the cells’ environment and this in turn helps to regulate the appropriate cellular responses. Abnormal protein modification can lead to disease, as it alters normal cell behaviour. Citrullination is one such chemical modification, which has gained great interest because it is associated with autoimmunity, neurodegeneration and cancer progression. Increased understanding of how citrullination comes about within cells will make it possible to target it effectively in disease therapy. In this theme issue, scientists working on various facets of citrullination research have come together to contribute their latest findings and summarize current knowledge, with the aim of driving progress in this area.

This issue arises from a Royal Society Theo Murphy meeting held in October 2022.

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INTRODUCTION

Introduction
Citrullination: new tricks for an old mod
Published:02 October 2023Article ID:20220235

https://doi.org/10.1098/rstb.2022.0235

ARTICLES

Research articles
Co-expression of PADI isoforms during progenitor differentiation enables functional diversity
Published:02 October 2023Article ID:20220451

https://doi.org/10.1098/rstb.2022.0451

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Review articles
Deimination in epidermal barrier and hair formation
Published:02 October 2023Article ID:20220245

https://doi.org/10.1098/rstb.2022.0245

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Research articles
Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells
Published:02 October 2023Article ID:20220236

https://doi.org/10.1098/rstb.2022.0236

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Research articles
Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice
Published:02 October 2023Article ID:20220475

https://doi.org/10.1098/rstb.2022.0475

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Review articles
Citrullination of matrisomal proteins in health and diseases
Published:02 October 2023Article ID:20220244

https://doi.org/10.1098/rstb.2022.0244

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Research articles
An unbiased proteomic analysis of PAD4 in human monocytes: novel substrates, binding partners and subcellular localizations
Published:02 October 2023Article ID:20220477

https://doi.org/10.1098/rstb.2022.0477

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Review articles
Citrulline is not a major determinant of autoantibody reactivity to neutrophil extracellular traps
Published:02 October 2023Article ID:20220249

https://doi.org/10.1098/rstb.2022.0249

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Research articles
Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia
Published:02 October 2023Article ID:20230042

https://doi.org/10.1098/rstb.2023.0042

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Research articles
Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3
Published:02 October 2023Article ID:20220247

https://doi.org/10.1098/rstb.2022.0247

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Review articles
Citrullination and the protein code: crosstalk between post-translational modifications in cancer
Published:02 October 2023Article ID:20220243

https://doi.org/10.1098/rstb.2022.0243

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Research articles
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells
Published:02 October 2023Article ID:20220246

https://doi.org/10.1098/rstb.2022.0246

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Review articles
PADI6: What we know about the elusive fifth member of the peptidyl arginine deiminase family
Published:02 October 2023Article ID:20220242

https://doi.org/10.1098/rstb.2022.0242

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Review articles
Characterizing citrullination by mass spectrometry-based proteomics
Published:02 October 2023Article ID:20220237

https://doi.org/10.1098/rstb.2022.0237

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Review articles
Protein citrullination: inhibition, identification and insertion
Published:02 October 2023Article ID:20220240

https://doi.org/10.1098/rstb.2022.0240

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Research articles
Small molecule activates citrullination through targeting PAD2
Published:02 October 2023Article ID:20220248

https://doi.org/10.1098/rstb.2022.0248

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CORRECTIONS

Correction
Correction: ‘Chimpanzee vowel-like sounds and voice quality suggest formant space expansion through the hominoid lineage’ (2021), by Grawunder et al.
Published:02 October 2023Article ID:20230319

https://doi.org/10.1098/rstb.2023.0319

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Philosophical Transactions of the Royal Society B: Biological Sciences cover image
20 November 2023
Volume 378Issue 1890

Editor-In-Chief

Professor Richard Dixon FRS
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